This one-off one-handed arcade modification from Ben Heck and John Jacobsen is a lovely piece of work. In essence it uses a mix of a one-handed mechanical grab-on joystick with switches, linked to weighted solenoids which remotely physically push the buttons on an arcade machine, powered by a drill battery.
Admittedly, people can use emulators and even hack cabinets to get around this particular issue, but that's not the point here. This gives someone the power to go to a gaming event and play many old-school games with as close to the original feel as is possible. Brilliant job.
Try this link for more on adapted arcade games, with much more to come.